HTE at AstraZeneca: A History from A-Z
Citation: Douglas, J.J.; Campbell, A.D., et. al. The Implementation and Impact of Chemical High-Throughput Experimentation at AstraZeneca. ACS Catal. 2015 , 15 , 5229-5256. https://pubs.acs.org/doi/10.1021/acscatal.4c07969 Summary Figure: Background: High-throughput experimentation is a tool/technique/method to figure out the optimized conditions for a reaction as fast as possible. This paper details the history of HTE at AstraZeneca, which I think offers a helpful description of the strengths and weaknesses of HTE and where the field currently stands. AstraZeneca first began using HTE around 2004-2005, with the establishment of a dedicated HTE lab in the UK. Setting up HTE is (or at least was in 2004) more complicated than buying a single instrument, as figuring out the right set up for them required the use of multiple different pieces of equipment. For example, a solid handling robot, a separate liquid handling robot, and a heating block/24-well plate for test...